Question about the imbalanced case-control ratio result of STAAR

[Youpu-Chen]

Hi there,

Thank you for developing this great meta-analysis toolkit.

I am currently using the result from STAARpipeline with the null model in SPA mode, which only output the result below:

Burden(1,25) | STAAR-B(1,25) | Burden(1,1) | STAAR-B(1,1) | STAAR-B

I am confused by the description in the MetaSTAAR tutorial below:

Because I only obtained one batch of summary statistics, therefore I was wondering that does these results cope with the MetaSTAAR procedure?

I'll really appreciate it if you could give me a hint.

Best,
Hongpu.

[Youpu-Chen]

Hi, Dr. Li,

Is there any utility could be applied to estimate the variance explained by the burden signal, which can be further applied to estimate or validate the statistical power of the burden signal?

Best,
Honpu.

[xihaoli]

Hi @Youpu-Chen,

Thanks for your message. Given that you have a couple of questions about STAAR-related tools, it would be most helpful to discuss them together. Please feel free to send us an email and we can discuss from there.

Best,
Xihao