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Welcome to the ProHap wiki! Here, I will demonstrate how to use ProHap to generate databases of protein sequences, and how to annotate and interpret the peptide identifications after using this database with a search engine.

This repository contains a Snakemake pipeline integrating two highly similar tools:

• ProHap: The main tool aimed at creating the databases of human protein haplotype sequences (using observed combinations of alleles in each transcript) from phased genotype data sets
• ProVar: Considers each allele independently, useful for adding rare variation into the resulting sequence database